In accordance with article 4, par. 4 of Regulation 2273/2003 of the Committee of European Union" ALAPIS HOLDING INDUSTRIAL AND COMMERCIAL SOCIETE ANONYME OF PHARMACEUTICAL, CHEMICAL AND ORGANIC PRODUCTS" announces that following the resolution of the General Meeting of the Shareholders dated February 4, 2008 and the Board of Directors' resolution dated June 26, 2008, and in accordance with article 16 of L.2190/1920, during the trading session of December 8th, 2008, acquired 820,000 own shares through "PIRAEUS AEPEY" at the average price of Euro 1.00 per share and the total value of the transaction amounted to Euros 820,800.00 .